Together with structural MRI, BOLD fMRI is increasingly being used for presurgical functional mapping of epilepsy and brain tumor patients ( Binder, et al., 1996 Haberg, Kvistad, Unsgard, & Haraldseth, 2004 Hall & Truwit, 2008 Krings, et al., 2001 Lee, et al., 1999 Van Westen, Skagerberg, Olsrud, Fransson, & Larsson, 2005 Liebenthal, 2011). Overview of fMRI and its use in presurgical mappingįunctional magnetic resonance imaging (fMRI) using the blood-oxygenation level dependent (BOLD) contrast measures local changes in the concentration of paramagnetic deoxyhemoglobin associated with an increase in blood flow to active regions of the brain ( Bandettini, Wong, Hinks, Tikofsky, & Hyde, 1992 Kwong, et al., 1992 Ogawa, Lee, Kay, & Tank, 1990).
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